The Cluster of Bioeconomy and Environment of Western Macedonia (CluBE) is a non-profit company established among local actors and stakeholders of the Region of Western Macedonia in Greece. CluBE emerged from the continuous collaboration of regional players during previous projects, analysing regional bioenergy and biomass potentials, the core cluster structures, and the regional innovation systems devoted to the energy sector. The mission of CluBE is to enhance collaboration and increase regional knowledge by promoting innovation and synergies between regional stakeholders in the fields of bioeconomy and environment. CluBE is developing R&D and business activities in the fields of bioeconomy, bioenergy, environment, green hydrogen, digital transition and climate policies in order to reinforce green, smart and circular economy in the region and the neighbouring areas.